Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Mutations of the SL2 dimerization sequence of the hepatitis C genome abrogate viral replication.

Cellular and molecular life sciences : CMLS - 1 Sept 2015

Masante Cyril, Jaubert Chloé, Palau William, Plissonneau Jacqueline, Besnard Lucie, Ventura Michel, Di Primo Carmelo

Abstract excerpt

Stem-loop SL2 is a self-interacting palindromic sequence that has been identified within the hepatitis C virus genome (HCV). While, RNA dimerization of the HCV genome has been observed in vitro with short RNA sequences, the role of a putative RNA dimerization during viral replication has not been elucidated. To determine the effect of genomic dimerization on viral replication, we introduced mutations into SL2...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Base Pairing
Share to Dimerization

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genetic Vectors

Share to Inverted Repeat Sequences

Share to Luciferases

Share to Oligonucleotides

Share to Surface Plasmon Resonance

Share to Virus Replication

Source

Open in PubMed Open full text

Identifiers

PMID: 25822205
DOI: 10.1007/s00018-015-1893-3
PMCID: PMC7079775

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Mutations of the SL2 dimerization sequence of the hepatitis C genome abrogate viral replication.PMID 25822205Read ↗

Hepatitis C virus genomic RNA dimerization is mediated via a kissing complex intermediateSemantic proximity Read ↗

Analysis of hepatitis C virus RNA dimerization and core-RNA interactions.Semantic proximity Read ↗

Role of stem B, loop B, and nucleotides next to the primer binding site and the kissing-loop domain in human immunodeficiency virus type 1 replication and genomic-RNA dimerization.Semantic proximity Read ↗

Direct evidence for RNA-RNA interactions at the 3' end of the Hepatitis C virus genome using surface plasmon resonance.Semantic proximity Read ↗

Impact of human immunodeficiency virus type 1 RNA dimerization on viral infectivity and of stem-loop B on RNA dimerization and reverse transcription and dissociation of dimerization from packaging.Semantic proximity Read ↗

Mutational analysis of the bipartite dimer linkage structure of human immunodeficiency virus type 1 genomic RNA.Semantic proximity Read ↗

A short sequence motif in the 5' leader of the HIV-1 genome modulates extended RNA dimer formation and virus replication.Semantic proximity Read ↗

Conserved determinants of lentiviral genome dimerization.Semantic proximity Read ↗

Palindromic sequence plays a critical role in human foamy virus dimerization.Semantic proximity Read ↗

An essential RNA element resides in a central region of hepatitis E virus ORF2.Semantic proximity Read ↗

An unexpected RNA distal interaction mode found in an essential region of the hepatitis C virus genome.Semantic proximity Read ↗

A Short Autocomplementary Sequence Plays an Essential Role in Avian Sarcoma−Leukosis Virus RNA DimerizationSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.