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Hepatitis C virus genomic RNA dimerization is mediated via a kissing complex intermediate

1 Apr 2010

Abstract excerpt

With over 200 million people infected with hepatitis C virus (HCV) worldwide, there is a need for more effective and better-tolerated therapeutic strategies. The HCV genome is a positive-sense; single-stranded RNA encoding a large polyprotein cleaved at multiple sites to produce at least ten proteins, among them an error-prone RNA polymerase that confers a high mutation rate. Despite considerable overall sequence...

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PMID: 20360391
DOI: 10.1261/rna.1960410

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