Article
Converging evidence implicates the abnormal microRNA system in schizophrenia.
Schizophrenia bulletin - 1 May 2015
Zhang Fuquan, Xu Yong, Shugart Yin Yao, Yue Weihua, Qi Guoyang, Yuan Guozhen, Cheng Zaohuo, Yao Jianjun, Wang Jidong, Wang Guoqiang, Cao Hongbao, Guo Wei, Zhou Zhenhe, Wang Zhiqiang, Tian Lin, Jin Chunhui, Yuan Jianmin, Liu Chenxing, Zhang Dai
Abstract excerpt
BACKGROUND: Previous findings are inconsistent; yet, converging evidence suggests an association between schizophrenia (SZ) and the impairment of posttranscriptional regulation of brain development through microRNA (miRNA) systems. METHODS: This study aims to (1) compare the overall frequency of 121 rare variants (RVs) in 59 genes associated with the miRNA system in genome-wide association studies (GWAS)-derived...
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