Article
Association study of MiRSNPs with schizophrenia, tardive dyskinesia and cognition.
Schizophrenia research - 1 Jul 2016
John Jibin, Bhatia Triptish, Kukshal Prachi, Chandna Puneet, Nimgaonkar Vishwajit L, Deshpande Smita N, Thelma B K
Abstract excerpt
MicroRNAs (miRNAs) bind to 3'UTRs of genes and negatively regulate their expression. With ~50% of miRNAs expressing in the brain, they play an important role in neuronal development, plasticity, cognition and neurological disorders. Conserved miRNA targets are present in >60% genes in humans and are under evolutionary pressure to maintain pairing with miRNA. However, such binding may be affected by genetic...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.