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Article

Fluoride-induced hypertension by regulating RhoA/ROCK pathway and phenotypic transformation of vascular smooth muscle cells: In vitro and in vivo evidence.

Ecotoxicology and environmental safety - 1 Aug 2024

Yang Wenjing, Lu Chunqing, Chu Fang, Bu Keming, Ma Hao, Wang Qiaoyu, Jiao Zhe, Wang Sheng, Yang Xiyue, Gao Yanhui, Sun Dianjun, Sun Hongna

Abstract excerpt

Fluoride exposure has been implicated as a potential risk factor for hypertension, but the underlying mechanisms remain unclear. This study investigated the role of the RhoA/ROCK signaling pathway in fluoride-induced hypertension. Male Wistar rats were divided into different groups and exposed to varying concentrations of sodium fluoride (NaF) or sodium chloride (NaCl) via drinking water. The rats' blood pressure...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 38964063
DOI: 10.1016/j.ecoenv.2024.116681

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

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