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Medium-Based Noninvasive Preimplantation Genetic Diagnosis for Human α-Thalassemias-SEA

1 Mar 2015

Abstract excerpt

To develop a noninvasive medium-based preimplantation genetic diagnosis (PGD) test for α-thalassemias-SEA. The embryos of α-thalassemia-SEA carriers undergoing in vitro fertilization (IVF) were cultured. Single cells were biopsied from blastomeres and subjected to fluorescent gap polymerase chain reaction (PCR) analysis; the spent culture media that contained embryo genomic DNA and corresponding blastocysts as...

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PMID: 25816038
DOI: 10.1097/md.0000000000000669

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