Article

Preimplantation Genetic Testing for Thalassemia Through Next- Generation Sequencing of Affected-embryos

2021-12-29

Abstract excerpt

<h4>Background: </h4> To evaluate the ability of next-generation sequencing (NGS) to conduct preimplantation genetic testing (PGT) for thalassemia using affected embryos. <h4>Methods: </h4>: This study included data from 36 couples who underwent PGT for thalassemia without proband and relative pedigrees. NGS results were compared with prenatal diagnosis results. <h4>Results: </h4>: Thirty-six couples (29 α-thalass...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 02bf3af6-5a56-5504-87a6-ccb810711c8a
DOI: 10.21203/rs.3.rs-1202545/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Preimplantation Genetic Testing for Thalassemia Through Next- Generation Sequencing of Affected-embryosDOI 10.21203/rs.3.rs-1202545/v1Read

Using affected embryos to establish linkage phase in preimplantation genetic testing for thalassemiaSemantic proximity Read

Hemoglobinopathies and preimplantation diagnosticsSemantic proximity Read

Application of third-generation sequencing technology in the genetic testing of thalassemiaSemantic proximity Read

Embryo genome profiling by single-cell sequencing for preimplantation genetic diagnosis in a β-thalassemia family.Semantic proximity Read

Technically feasible solutions to challenges in preimplantation genetic testing for thalassemia: experiences of multiple centers between 2019 and 2022.Semantic proximity Read

Clinical utility of combined preimplantation genetic testing methods in couples at risk of passing on beta thalassemia/hemoglobin E disease: A retrospective review from a single center.Semantic proximity Read

Advancements and Applications of Preimplantation Genetic Testing in In Vitro Fertilization: A Comprehensive ReviewSemantic proximity Read

Incremental Clinical Value of Single-Molecule Nanopore Sequencing in Thalassemia Testing: A Prospective, Double-blind, Multicenter StudySemantic proximity Read

Integration of targeted sequencing and pseudo-tetraploid genotyping into clinically assisted decision support for β-thalassemia invasive prenatal diagnosis.Semantic proximity Read

The Evolving Role of Next-Generation Sequencing in Screening and Diagnosis of HemoglobinopathiesSemantic proximity Read

Appropriate whole genome amplification and pathogenic loci detection can improve the accuracy of preimplantation genetic diagnosis for deletional α-thalassemia.Semantic proximity Read

[Preimplantation Genetic Diagnosis of α/β Complex Thalassemia by Next Generation Sequencing].Semantic proximity Read