Article
Successful preimplantation genetic diagnosis for alpha- and beta-thalassemia in China.
Prenatal diagnosis - 1 Nov 2006
Deng Jie, Peng Wen-Lin, Li Jie, Fang Cong, Liang Xiao-Yan, Zeng Yan-Hong, Sun Hong-Yu, Zhou Can-Quan, Zhuang Guang-Lun
Abstract excerpt
METHODS & RESULTS: In southern China, the average carrier rates of alpha-thalassemia and beta-thalassemia in the population are as high as 10.3% and 2.8%, respectively. Because of the high rates, they are known as 'social diseases' in some regions. In this study, the fluorescent gap PCR, which can detect the alpha-thalassemia Southeast Asia deletion (SEA deletion), was applied in four clinical applications of...
Topics
- Adult
- Alleles
- Asian People
- China
- Female
- Heterozygote
- Humans
- Male
- Mutation
- Polymerase Chain Reaction
- Pregnancy
- Preimplantation Diagnosis
- Prenatal Diagnosis
- alpha-Thalassemia
- beta-Thalassemia