Article
Non-invasive pre-implantation aneuploidy screening and diagnosis of beta thalassemia IVSII654 mutation using spent embryo culture medium.
Annals of medicine - 1 Jun 2017
Liu WeiQiang, Liu JianQiao, Du HongZi, Ling JiaWei, Sun XiaoFang, Chen DunJin
Abstract excerpt
BACKGROUND: Cell-free nuclear DNA has been isolated from spent embryo culture medium. Whether this small amount of DNA can be amplified at the whole genome level and the concordance rate of karyotypes and specific alleles between biopsied cells and media has not been evaluated. METHODS: Seven couples were recruited, 88 donated embryos and their corresponding media were collected for whole genome amplification...
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