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Article

Development of pre-implantation genetic testing protocol for monogenic disorders (PGT-M) of Hb H disease.

BMC genomics - 3 Jul 2024

Somboonchai Pannarai, Charoenkwan Pimlak, Piyamongkol Sirivipa, Lattiwongsakorn Worashorn, Pantasri Tawiwan, Piyamongkol Wirawit

Abstract excerpt

Hb H disease is the most severe form of α-thalassemia compatible with post-natal life. Compound heterozygous α0-thalassemia- SEA deletion/α+-thalassemia- 3.7kb deletion is the commonest cause of Hb H disease in Thailand. Preimplantation genetics testing for monogenic disorders (PGT-M) is an alternative for couples at risk of the disorder to begin a pregnancy with a healthy baby. This study aims to develop a novel...

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Identifiers

PMID: 38961367
DOI: 10.1186/s12864-024-10578-7
PMCID: PMC11223301

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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