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Article

Mosaic BRAF Fusions Are a Recurrent Cause of Congenital Melanocytic Nevi Targetable by MAPK Pathway Inhibition.

The Journal of investigative dermatology - 1 Mar 2024

Martin Sara Barberan, Polubothu Satyamaanasa, Bruzos Alicia Lopez, Kelly Gavin, Horswell Stuart, Sauvadet Aimie, Bryant Dale, Zecchin Davide, Riachi Melissa, Michailidis Fanourios, Sadri Amir, Muwanga-Nanyonjo Noreen, Lopez-Balboa Pablo, Knöpfel Nicole, Bulstrode Neil, Pittman Alan, Yeh Iwei, Kinsler Veronica A

Abstract excerpt

Among children with multiple congenital melanocytic nevi, 25% have no established genetic cause, of whom many develop a hyperproliferative and severely pruritic phenotype resistant to treatment. Gene fusions have been reported in individual cases of congenital melanocytic nevi. We studied 169 patients with congenital melanocytic nevi in this study, 38 of whom were double wild type for pathogenic NRAS/BRAF...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 37716647
DOI: 10.1016/j.jid.2023.06.213

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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