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Article

Multiple congenital melanocytic nevi and neurocutaneous melanosis are caused by postzygotic mutations in codon 61 of NRAS.

The Journal of investigative dermatology - 1 Sept 2013

Kinsler Veronica A, Thomas Anna C, Ishida Miho, Bulstrode Neil W, Loughlin Sam, Hing Sandra, Chalker Jane, McKenzie Kathryn, Abu-Amero Sayeda, Slater Olga, Chanudet Estelle, Palmer Rodger, Morrogh Deborah, Stanier Philip, Healy Eugene, Sebire Neil J, Moore Gudrun E

Abstract excerpt

Congenital melanocytic nevi (CMN) can be associated with neurological abnormalities and an increased risk of melanoma. Mutations in NRAS, BRAF, and Tp53 have been described in individual CMN samples; however, their role in the pathogenesis of multiple CMN within the same subject and development of associated features has not been clear. We hypothesized that a single postzygotic mutation in NRAS could be...

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Identifiers

PMID: 23392294
DOI: 10.1038/jid.2013.70
PMCID: PMC3678977

Genes

NRAS
BRAF

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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