Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The retinal phenotype of Grk1-/- is compromised by a Crb1 rd8 mutation.

Molecular vision - 1 Jan 2015

Pak Joseph S, Lee Eun-Jin, Craft Cheryl Mae

Abstract excerpt

PURPOSE: Well-established laboratory mouse lines are important in creating genetically engineered knockout mouse models; however, these routinely used inbred strains are prone to spontaneous and deleterious mutations. One of these strains, the commonly used C57BL/6N (B6N), was discovered to carry a point mutation in the Crumbs homolog 1 (Crb1(rd8) ) gene, which codes for a developmental protein involved in tight...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Age Factors
Share to Darkness
Share to Glial Fibrillary Acidic Protein

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to In Situ Nick-End Labeling

Share to Photic Stimulation

Share to Photoreceptor Cells, Vertebrate

Share to Retinal Degeneration

Share to Zonula Occludens-1 Protein

Source

Open in PubMed Open full text

Identifiers

PMID: 26664249
PMCID: PMC4663191

Genes

GFAP
GRK1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The retinal phenotype of Grk1-/- is compromised by a Crb1 rd8 mutation.PMID 26664249Read ↗

Identification of Arhgef12 and Prkci as genetic modifiers of retinal dysplasia in the Crb1rd8 mouse model.Semantic proximity Read ↗

Identification of <i>Arhgef12</i> and <i>Prkci</i> as Genetic Modifiers of Retinal Dysplasia in the <i> Crb1 <sup>rd8</sup> </i> Mouse ModelSemantic proximity Read ↗

The severity of retinal pathology in homozygous Crb1rd8/rd8 mice is dependent on additional genetic factors.Semantic proximity Read ↗

The Rd8 mutation of the Crb1 gene is present in vendor lines of C57BL/6N mice and embryonic stem cells, and confounds ocular induced mutant phenotypes.Semantic proximity Read ↗

CRB1 is essential for external limiting membrane integrity and photoreceptor morphogenesis in the mammalian retinaSemantic proximity Read ↗

Mthfr as a modifier of the retinal phenotype of Crb1(rd8/rd8) mice.Semantic proximity Read ↗

Loss of CRB2 in the mouse retina mimics human retinitis pigmentosa due to mutations in the CRB1 gene.Semantic proximity Read ↗

Human CRB1-associated retinal degeneration: comparison with the rd8 Crb1-mutant mouse model.Semantic proximity Read ↗

A Population Study of Common Ocular Abnormalities in C57BL/6N rd8 Mice.Semantic proximity Read ↗

Presence of rd8 mutation does not alter the ocular phenotype of late-onset retinal degeneration mouse model.Semantic proximity Read ↗

Microarray and morphological analysis of early postnatal CRB2 mutant retinas on a pure C57BL/6J genetic background.Semantic proximity Read ↗

Loss of CRB2 in Müller glial cells modifies a CRB1-associated retinitis pigmentosa phenotype into a Leber congenital amaurosis phenotypeSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.