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Can the simple chicken MHC provide insight into the balance of autoimmunity and infectious disease?

Immunogenetics - 29 Dec 2025

Mararo Enock M, Goryanin Anastasia, Kaufman Jim

Abstract excerpt

The major histocompatibility complex (MHC) plays a central role in immune responses, with strong links to both infectious disease resistance and autoimmune conditions. In typical mammals, such as humans, the MHC is large and complex, comprising many genes and exhibiting weak associations with infectious diseases, but strong associations with autoimmunity. In contrast, the chicken MHC is small and simple, with...

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PMID: 41457179
DOI: 10.1007/s00251-025-01394-8

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