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Article

Development of a gLCR-based KRAS mutation detection approach and its comparison with other screening methods.

Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine - 1 Aug 2015

Jenner Stefan, Techel Dieter

Abstract excerpt

A gapped ligase chain reaction (gLCR)-based technique was developed and tested on clinical formalin-fixed, paraffin-embedded (FFPE) tissues from colorectal cancer patients. The technique was designed to detect low-level KRAS codon 12 or 13 mutations or confirming doubtful results gained by less sensitive KRAS screening techniques. The gLCR approach was compared with mutation screening techniques commonly used in...

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PMID: 25813150
DOI: 10.1007/s13277-015-3323-4

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KRAS

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