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Telomerase expression and telomere length in breast cancer and their associations with adjuvant treatment and disease outcome

6 Jun 2011

Abstract excerpt

INTRODUCTION: Telomere length plays important roles in maintaining genome stability and regulating cell replication and death. Telomerase has functions not only to extend telomere length but also to repair DNA damage. Studies have shown that telomerase may increase cancer cell resistance to DNA-damaging anticancer agents; tamoxifen may suppress telomerase expression in breast cancer cells. This study aimed to...

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PMID: 21645396
DOI: 10.1186/bcr2893

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