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Article

Src-family protein tyrosine kinase phosphorylates WNK4 and modulates its inhibitory effect on KCNJ1 (ROMK).

Proceedings of the National Academy of Sciences of the United States of America - 7 Apr 2015

Lin Dao-Hong, Yue Peng, Yarborough Orlando, Scholl Ute I, Giebisch Gerhard, Lifton Richard P, Rinehart Jesse, Wang Wen-Hui

Abstract excerpt

With-no-lysine kinase 4 (WNK4) inhibits the activity of the potassium channel KCNJ1 (ROMK) in the distal nephron, thereby contributing to the maintenance of potassium homeostasis. This effect is inhibited via phosphorylation at Ser1196 by serum/glucocorticoid-induced kinase 1 (SGK1), and this inhibition is attenuated by the Src-family protein tyrosine kinase (SFK). Using Western blot and mass spectrometry, we now...

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Source

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Identifiers

PMID: 25805816
DOI: 10.1073/pnas.1503437112
PMCID: PMC4394290

Genes

WNK4
SGK1
KCNJ1

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Src-family protein tyrosine kinase phosphorylates WNK4 and modulates its inhibitory effect on KCNJ1 (ROMK).PMID 25805816Read ↗

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