Association of a 62 Variants Type 2 Diabetes Genetic Risk Score With Markers of Subclinical Atherosclerosis: A Transethnic, Multicenter Study.

doi:10.1161/CIRCGENETICS.114.000740

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Article

Association of a 62 Variants Type 2 Diabetes Genetic Risk Score With Markers of Subclinical Atherosclerosis: A Transethnic, Multicenter Study.

Circulation. Cardiovascular genetics - 1 Jun 2015

Dauriz Marco, Porneala Bianca C, Guo Xiuqing, Bielak Lawrence F, Peyser Patricia A, Durant Nefertiti H, Carnethon Mercedes R, Bonadonna Riccardo C, Bonora Enzo, Bowden Donald W, Florez Jose C, Fornage Myriam, Hivert Marie-France, Jacobs David R, Kabagambe Edmond K, Lewis Cora E, Murabito Joanne M, Rasmussen-Torvik Laura J, Rich Stephen S, Vassy Jason L, Yao Jie, Carr Jeffrey J, Kardia Sharon L R, Siscovick David, O'Donnell Christopher J, Rotter Jerome I, Dupuis Josée, Meigs James B

Abstract excerpt

BACKGROUND: Type 2 diabetes mellitus (T2D) and cardiovascular disease share risk factors and subclinical atherosclerosis (SCA) predicts events in those with and without diabetes mellitus. T2D genetic risk may predict both T2D and SCA. We hypothesized that greater T2D genetic risk is associated with higher extent of SCA. METHODS AND RESULTS: In a cross-sectional analysis, including ≤9210 European Americans, 3773...

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PMID: 25805414
DOI: 10.1161/CIRCGENETICS.114.000740
PMCID: PMC4472563

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