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Article

The Role of Genetics in Malignant Melanoma: A Comprehensive Review.

The Surgical clinics of North America - 1 Aug 2026

Smith Shannon M, Wright G Paul

Abstract excerpt

Malignant melanoma represents a lethal cutaneous malignancy. This review article highlights somatic mutations as well as high- and moderate-penetrance germline genetic mutations frequently found in melanoma. BRAF and CDKN2A remain the most frequently identified somatic and germline mutations respectively; however, numerous others have been implicated including KRAS, c-KIT, CDK4, BAP1, TERT, POT1, ACD/TERF2IP and...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 42419313
DOI: 10.1016/j.suc.2026.03.010

Genes

ACD
ATM
BAP1
BRAF
CDK4
CDKN2A
KIT
KRAS
POT1
TERF2IP
TERT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 23 Oct 2026.

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