Article
Melanoma susceptibility genes and risk assessment.
Methods in molecular biology (Clifton, N.J.) - 1 Jan 2014
Marzuka-Alcalá Alexander, Gabree Michele Jacobs, Tsao Hensin
Abstract excerpt
Familial melanoma accounts for approximately a tenth of all melanoma cases. The most commonly known melanoma susceptibility gene is the highly penetrant CDKN2A (p16INK4a) locus, which is transmitted in an autosomal dominant fashion and accounts for approximately 20-50 % of familial melanoma cases. Mutated p16INK4a shows impaired capacity to inhibit the cyclin D1-CDK4 complex, allowing for unchecked cell cycle...
Topics
- Genes, Neoplasm
- Genetic Predisposition to Disease
- Humans
- Melanoma
- Risk Assessment
- Skin Neoplasms