Article
Variant rs1801157 in the 3'UTR of SDF-1ß does not explain variability of healthy-donor G-CSF responsiveness.
PloS one - 1 Jan 2015
Schulz Miriam, Karpova Darja, Spohn Gabriele, Damert Annette, Seifried Erhard, Binder Vera, Bönig Halvard
Abstract excerpt
The genetics responsible for the inter-individually variable G-CSF responsiveness remain elusive. A single nucleotide polymorphism (SNP) in the 3'UTR of CXCL12, rs1801157, was implicated in X4-tropic HiV susceptibility and later, in two small studies, in G-CSR responsiveness in patients and donors. The position of the SNP in the 3'UTR together with in-silico predictions suggested differential binding of...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.