Article
The effect of granulocyte colony stimulating factor receptor gene missense single nucleotide polymorphisms on peripheral blood stem cell enrichment.
Cytokine - 1 Feb 2013
Camurdanoglu Bahar Z, Esendagli Gunes, Ozdemir Evren, Canpinar Hande, Guc Dicle, Kansu Emin
Abstract excerpt
Granulocyte-colony stimulating factor (G-CSF) has become the most effective agent supporting hematopoietic stem cell transplantation (HSCT). The cognate interaction between G-CSF and its specific receptor, G-CSFR, induces the mobilization of HSCs and increases their pool in the peripheral blood. G-CSFR has a highly conserved structure which may be functionally modulated by the presence of missense single...
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