Article
Analysis of a large single institution cohort of related donors fails to detect a relation between SDF1/CXCR4 or VCAM/VLA4 genetic polymorphisms and the level of hematopoietic progenitor cell mobilization in response to G-CSF.
PloS one - 1 Jan 2020
Garciaz Sylvain, Sfumato Patrick, Granata Angela, Imbert Anne-Marie, Fournel Claire, Calmels Boris, Lemarie Claude, Chiaroni Jacques, Blaise Didier, Boher Jean-Marie, Picard Christophe, Chabannon Christian, di Cristofaro Julie
Abstract excerpt
We studied a cohort of 367 healthy related donors who volunteered to donate their hematopoietic stem cells for allogeneic transplantation. All donors were homogeneously cared for at a single institution, and received rhG-CSF as a mobilization treatment prior to undergoing apheresis. Peripheral blood CD34+ cell counts were used as the main surrogate marker for rhG-CSF induced mobilization. We searched whether...
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