Article
Contribution of genetics to hematopoietic stem cell mobilization: a genome-wide association study of 564 healthy donors mobilized with granulocyte colony-stimulating factor.
Haematologica - 1 Nov 2025
Stenzinger Miriam, Beck Susanne, Ourailidis Iordanis, Volckmar Anna-Lena, Paramasivam Nagarajan, Ahadova Aysel, Portilla Aitzkoa Lopez de Lapuente, La Yen Phuong, Nilsson Bjorn, Bermejo Justo Lorenzo, Bonig Halvard, Budczies Jan
Abstract excerpt
Hematopoietic stem and progenitor cells (HSPC) from mobilized blood are the preferred graft source for allogeneic and autologous stem cell transplantation. The efficiency of CD34+ cell mobilization with granulocyte colony-stimulating factor (G-CSF) varies significantly between individuals, but is reproducible across mobilization cycles within an individual, suggesting a genetic component, a hypothesis that has...
Read the complete abstract on PubMedTopics
- Humans
- Hematopoietic Stem Cell Mobilization
- Granulocyte Colony-Stimulating Factor
- Genome-Wide Association Study