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Article

Impact of constitutional polymorphisms in VCAM1 and CD44 on CD34+ cell collection yield after administration of granulocyte colony-stimulating factor to healthy donors.

Haematologica - 1 Jan 2011

Martín-Antonio Beatriz, Carmona Magdalena, Falantes Jose, Gil Encarnación, Baez Alicia, Suarez María, Marín Pedro, Espigado Ildefonso, Urbano-Ispizua Alvaro

Abstract excerpt

UNLABELLED: Background The number of CD34(+) cells mobilized from bone marrow to peripheral blood after administration of granulocyte colony-stimulating factor varies greatly among healthy donors. This fact might be explained, at least in part, by constitutional differences in genes involved in the interactions tethering CD34(+) cells to the bone marrow. DESIGN AND METHODS: We analyzed genetic characteristics...

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Topics

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Share to Antigens, CD34
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Granulocyte Colony-Stimulating Factor

Share to Hematopoietic Stem Cell Mobilization

Share to Hyaluronan Receptors

Share to Receptors, Colony-Stimulating Factor

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Share to Vascular Cell Adhesion Molecule-1

Source

Open in PubMed Open full text

Identifiers

PMID: 20851866
DOI: 10.3324/haematol.2010.026401
PMCID: PMC3012773

Genes

VCAM1
CXCL12
CXCR4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

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Impact of constitutional polymorphisms in VCAM1 and CD44 on CD34+ cell collection yield after administration of granulocyte colony-stimulating factor to healthy donors.PMID 20851866Read ↗

Polymorphism of CD44 influences the efficacy of CD34(+) cells mobilization in patients with hematological malignancies.Semantic proximity Read ↗

Analysis of a large single institution cohort of related donors fails to detect a relation between SDF1/CXCR4 or VCAM/VLA4 genetic polymorphisms and the level of hematopoietic progenitor cell mobilization in response to G-CSF.Semantic proximity Read ↗

Impact of CD44 gene single nucleotide polymorphism (rs 13347) in mobilization of autologous HSCT.Semantic proximity Read ↗

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Association of stromal cell-derived factor-1-3'A polymorphism to higher mobilization of hematopoietic stem cells CD34+ in Tunisian population.Semantic proximity Read ↗

Circulating CD34+ progenitor cell frequency is associated with clinical and genetic factorsSemantic proximity Read ↗

Single nucleotide polymorphisms of the DGKB and VCAM1 genes are associated with granulocyte colony stimulating factor-mediated peripheral blood stem cell mobilization.Semantic proximity Read ↗

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The CXCL12-3'A allele is associated with a higher mobilization yield of CD34 progenitors to the peripheral blood of healthy donors for allogeneic transplantation.Semantic proximity Read ↗

The plasma levels of soluble HLA-G molecules correlate directly with CD34+ cell concentration and HLA-G 14bp insertion/insertion polymorphism in cord blood donors.Semantic proximity Read ↗

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