Article
High circulating SDF-1and MCP-1 levels and genetic variations in CXCL12, CCL2 and CCR5: Prognostic signature of immune recovery status in treated HIV-positive patients.
EBioMedicine - 1 Dec 2020
Yeregui Elena, Viladés Consuelo, Domingo Pere, Ceausu Andra, Pacheco Yolanda María, Veloso Sergi, Inciarte Alexy, Vidal-González Judit, Peraire Maria, Perpiñán Carles, Falcó Vicenç, Masip Jenifer, Alba Verónica, Vargas Montserrat, Martí Anna, Reverté Laia, Mallolas Josep, Vidal Francesc, Peraire Joaquim, Rull Anna
Abstract excerpt
BACKGROUND: The underlying mechanisms of incomplete immune reconstitution in treated HIV-positive patients are very complex and may be multifactorial, but perturbation of chemokine secretion could play a key role in CD4+T-cell turnover. METHODS: We evaluated the circulating baseline and 48-week follow-up concentrations of SDF-1/CXCL12, fractalkine/CX3CL1, MCP-1/CCL2, MIP-α/CCL3, MIP-β/CCL4 and RANTES/CCL5, and we...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.