Article
New somatic mutations and WNK1-B4GALNT3 gene fusion in papillary thyroid carcinoma.
Oncotarget - 10 May 2015
Costa Valerio, Esposito Roberta, Ziviello Carmela, Sepe Romina, Bim Larissa Valdemarin, Cacciola Nunzio Antonio, Decaussin-Petrucci Myriam, Pallante Pierlorenzo, Fusco Alfredo, Ciccodicola Alfredo
Abstract excerpt
Papillary thyroid carcinoma (PTC) is the most frequent thyroid malignant neoplasia. Oncogene activation occurs in more than 70% of the cases. Indeed, about 40% of PTCs harbor mutations in BRAF gene, whereas RET rearrangements (RET/PTC oncogenes) are present in about 20% of cases. Finally, RAS mutations and TRK rearrangements account for about 5% each of these malignancies. We used RNA-Sequencing to identify...
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