Article
APOE ε4 Genotype and the Risk for Subjective Cognitive Impairment in Elderly Persons.
The Journal of neuropsychiatry and clinical neurosciences - 1 Jan 2015
Krell-Roesch Janina, Woodruff Bryan K, Acosta Jazmin I, Locke Dona E, Hentz Joseph G, Stonnington Cynthia M, Stokin Gorazd B, Nagle Chelsea, Michel Bernard F, Sambuchi Nathalie, Caselli Richard J, Geda Yonas E
Abstract excerpt
The authors compared the risk for subjective cognitive impairment (SCI) between carriers of the apolipoprotein E ε4 (APOE ε4) allele (cases) and APOE ε4 noncarriers (controls). SCI was assessed by a validated self-reported questionnaire. The authors used multivariable logistic regression analyses to compute odds ratios and 95% confidence intervals adjusted for age, sex, education, and marital status. Data were...
Topics
- Adult
- Aged
- Aged, 80 and over
- Aging
- Alleles
- Apolipoproteins E
- Cognition Disorders
- Female
- Genetic Predisposition to Disease
- Genotype