MiR-217 mediates the protective effects of the dopamine D2 receptor on fibrosis in human renal proximal tubule cells.

doi:10.1161/HYPERTENSIONAHA.114.05096

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Article

MiR-217 mediates the protective effects of the dopamine D2 receptor on fibrosis in human renal proximal tubule cells.

Hypertension (Dallas, Tex. : 1979) - 1 May 2015

Han Fei, Konkalmatt Prasad, Chen Jianghua, Gildea John, Felder Robin A, Jose Pedro A, Armando Ines

Abstract excerpt

Lack or downregulation of the dopamine D2 receptor (D2R) increases the vulnerability to renal inflammation independent of blood pressure in mice. Common single nucleotide polymorphisms (SNPs) rs6276, 6277, and 1800497 in the human D2R gene are associated with decreased receptor expression/function and hypertension. Human renal proximal tubule cells from subjects carrying these SNPs have decreased D2R expression...

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Identifiers

PMID: 25801876
DOI: 10.1161/HYPERTENSIONAHA.114.05096
PMCID: PMC4393363

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