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Article

Kinetic and structural analysis of Escherichia coli phosphoenolpyruvate carboxykinase mutants.

Biochimica et biophysica acta. General subjects - 1 Apr 2020

Sokaribo Akosiererem, Novakovski Brian A A, Cotelesage Julien, White Aaron P, Sanders David, Goldie Hughes

Abstract excerpt

BACKGROUND: Phosphoenolpyruvate carboxykinase (PEPCK) is a metabolic enzyme in the gluconeogenesis pathway, where it catalyzes the reversible conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) and CO2. The substrates for Escherichia coli PEPCK are OAA and MgATP, with Mn2+ acting as a cofactor. Analysis of PEPCK structures have revealed amino acid residues involved in substrate/cofactor coordination...

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Identifiers

PMID: 31911238
DOI: 10.1016/j.bbagen.2020.129517

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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