Article

Biophysical and biochemical evidence for the role of acetate kinases (AckAs) in an acetogenic pathway in pathogenic spirochetes

2024-10-13

Abstract excerpt

Unraveling the metabolism of Treponema pallidum is a key component to understanding the pathogenesis of the human disease that it causes, syphilis. For decades, it was assumed that glucose was the sole carbon/energy source for this parasitic spirochete. But the lack of citric-acid-cycle enzymes suggested that alternative sources could be utilized, especially in microaerophilic host environments where glycolysis s...

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Literature Corpus work: ca0f5fe8-7692-55b9-87ea-dc0812e8849f
DOI: 10.1101/2024.10.12.617992

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