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Article

Absence of germline mutations in BAP1 in sporadic cases of malignant mesothelioma.

Gene - 25 May 2015

Sneddon Sophie, Leon Justine S, Dick Ian M, Cadby Gemma, Olsen Nola, Brims Fraser, Allcock Richard J N, Moses Eric K, Melton Phillip E, de Klerk Nicholas, Musk A W Bill, Robinson Bruce W S, Creaney Jenette

Abstract excerpt

Malignant mesothelioma (MM) is a uniformly fatal tumour caused predominantly by exposure to asbestos. It is not known why some exposed individuals get mesothelioma and others do not. There is some epidemiological evidence of host susceptibility. BAP1 gene somatic mutations and allelic loss are common in mesothelioma and recently a BAP1 cancer syndrome was described in which affected individuals and families had...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 25796603
DOI: 10.1016/j.gene.2015.03.031

Genes

BAP1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Absence of germline mutations in BAP1 in sporadic cases of malignant mesothelioma.PMID 25796603Read ↗

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A Subset of Mesotheliomas With Improved Survival Occurring in Carriers ofBAP1and Other Germline MutationsSemantic proximity Read ↗

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Sensitivity to asbestos is increased in patients with mesothelioma and pathogenic germline variants in BAP1 or other DNA repair genesSemantic proximity Read ↗

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