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Article

HDAC6 mutations rescue human tau-induced microtubule defects in Drosophila.

Proceedings of the National Academy of Sciences of the United States of America - 19 Mar 2013

Xiong Ying, Zhao Kai, Wu Jiaxi, Xu Zhiheng, Jin Shan, Zhang Yong Q

Abstract excerpt

Neurons from the brains of Alzheimer's disease (AD) and related tauopathy patients contain neurofibrillary tangles composed of hyperphosphorylated tau protein. Tau normally stabilizes microtubules (MTs); however, tau hyperphosphorylation leads to loss of this function with consequent MT destabilization and neuronal dysfunction. Accordingly, MT-stabilizing drugs such as paclitaxel and epothilone D have been shown...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 23487739
DOI: 10.1073/pnas.1207586110
PMCID: PMC3606981

Genes

HDAC6

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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