Article
Distinct clinical characteristics of myeloproliferative neoplasms with calreticulin mutations.
Haematologica - 1 Jul 2014
Andrikovics Hajnalka, Krahling Tunde, Balassa Katalin, Halm Gabriella, Bors Andras, Koszarska Magdalena, Batai Arpad, Dolgos Janos, Csomor Judit, Egyed Miklos, Sipos Andrea, Remenyi Peter, Tordai Attila, Masszi Tamas
Abstract excerpt
Somatic insertions/deletions in the calreticulin gene have recently been discovered to be causative alterations in myeloproliferative neoplasms. A combination of qualitative and quantitative allele-specific polymerase chain reaction, fragment-sizing, high resolution melting and Sanger-sequencing was applied for the detection of three driver mutations (in Janus kinase 2, calreticulin and myeloproliferative...
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