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Article

High ABCC2 and low ABCG2 gene expression are early events in the colorectal adenoma-carcinoma sequence.

PloS one - 1 Jan 2015

Andersen Vibeke, Vogel Lotte K, Kopp Tine Iskov, Sæbø Mona, Nonboe Annika W, Hamfjord Julian, Kure Elin H, Vogel Ulla

Abstract excerpt

Development of colorectal cancer (CRC) may result from a dysfunctional interplay between diet, gut microbes and the immune system. The ABC transport proteins ABCB1 (P-glycoprotein, Multidrug resistance protein 1, MDR1), ABCC2 (MRP2) and ABCG2 (BCRP) are involved in transport of various compounds...

Read the complete abstract on PubMed

Topics

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Share to Adenoma
Share to ATP Binding Cassette Transporter, Subfamily G, Member 2
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Colorectal Neoplasms

Share to Intestinal Mucosa

Share to Multidrug Resistance-Associated Protein 2

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Share to Neoplasm Proteins

Source

Open in PubMed Open full text

Identifiers

PMID: 25793771
DOI: 10.1371/journal.pone.0119255
PMCID: PMC4368545

Genes

ABCC2
ABCG2
ABCB1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-25793771-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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