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Article

The role of ABC transporters in progression and clinical outcome of colorectal cancer

31 Jan 2012

Abstract excerpt

Worldwide, colorectal cancer (CRC) is the third most common cancer, with the highest mortality rates occurring in Central Europe. The use of chemotherapy to treat CRC is limited by the inter-individual variability in drug response and the development of cancer cell resistance. ATP-binding cassette (ABC) transporters play a crucial role in the development of resistance by the efflux of anticancer agents outside of...

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PMID: 22294766
DOI: 10.1093/mutage/ger075

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