CD40 ligand stimulation affects the number and memory phenotypes of human peripheral CD8+ T cells.

Abstract excerpt

BACKGROUND: CD40L is primarily expressed on activated CD4+ T cells and binds to CD40 which is expressed by various cells including dendritic cells, macrophages and B lymphocytes. While CD40-CD40L interaction is known to be direct between B cells and CD4+ T cells which results in proliferation and immunoglobulin isotype switching, antigen presenting cells (APCs) were thought to be involved in the delivery of CD4+...

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• Share to Antigen-Presenting Cells
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• Share to CD40 Ligand