Article
An antibody combination that targets activated T cells extends graft survival in sensitized recipients.
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons - 1 Nov 2008
Greenlaw R E, Gardner N J, Farrar C A, Shariff H, Sacks S H, Yagita H, Simpson E, Jurcevic S
Abstract excerpt
Memory T cells are the very essence of adaptive immunity with their rapid and efficient response to antigen rechallenge and long-term persistence. However, it is becoming increasingly evident that when primed with self or transplanted tissue, these cells play a key role in causing and perpetuating tissue damage. Furthermore, current treatments, which efficiently control the naive response, have limited effects on...
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