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Article

pVHL and PTEN tumour suppressor proteins cooperatively suppress kidney cyst formation.

The EMBO journal - 18 Jun 2008

Frew Ian J, Thoma Claudio R, Georgiev Strahil, Minola Andrea, Hitz Manuela, Montani Matteo, Moch Holger, Krek Wilhelm

Abstract excerpt

In patients with von Hippel-Lindau (VHL) disease, renal cysts and clear cell renal cell carcinoma (ccRCC) arise from renal tubular epithelial cells containing biallelic inactivation of the VHL tumour suppressor gene. However, it is presumed that formation of renal cysts and their conversion to ccRCC involve additional genetic changes at other loci. Here, we show that cystic lesions in the kidneys of patients with...

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Share to Glycogen Synthase Kinase 3

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Source

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Identifiers

PMID: 18497742
DOI: 10.1038/emboj.2008.96
PMCID: PMC2435131

Genes

VHL
PTEN

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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