Article
Genetic Deficiency of Mtdh Gene in Mice Causes Male Infertility via Impaired Spermatogenesis and Alterations in the Expression of Small Non-coding RNAs.
The Journal of biological chemistry - 8 May 2015
Meng Xiangbing, Yang Shujie, Zhang Yuping, Wang Xinjun, Goodfellow Renee X, Jia Yichen, Thiel Kristina W, Reyes Henry D, Yang Baoli, Leslie Kimberly K
Abstract excerpt
Increased expression of metadherin (MTDH, also known as AEG-1 and 3D3/LYRIC) has been associated with drug resistance, metastasis, and angiogenesis in a variety of cancers. However, the specific mechanisms through which MTDH is involved in these processes remain unclear. To uncover these mechanisms, we generated Mtdh knock-out mice via a targeted disruption of exon 3. Homozygous Mtdh knock-out mice are viable,...
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