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Article

Identification of novel variants of metadherin in breast cancer.

PloS one - 8 Mar 2011

Liu Xianqiang, Zhang Ning, Li Xiao, Moran Meena S, Yuan Cunzhong, Yan Shi, Jiang Liyu, Ma Tingting, Haffty Bruce G, Yang Qifeng

Abstract excerpt

Metadherin (MTDH, also known as AEG-1, and Lyric) has been demonstrated to play a potential role in several significant aspects of tumor progression. It has been reported that overexpression of MTDH is associated with progression of disease and poorer prognosis in breast cancer. However, there are no studies to date assessing variants of the MTDH gene and their potential relationship with breast cancer...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 21408129
DOI: 10.1371/journal.pone.0017582
PMCID: PMC3050918

Genes

MTDH

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Identification of novel variants of metadherin in breast cancer.PMID 21408129Read ↗

Metadherin: An emerging key regulator of the malignant progression of multiple cancersSemantic proximity Read ↗

MTDH-SND1 interaction is crucial for expansion and activity of tumor-initiating cells in diverse oncogene- and carcinogen-induced mammary tumors.Semantic proximity Read ↗

Comprehensive pan‑cancer analysis of MTDH for human tumor prognosis and as an immunological biomarker including breast and kidney cancerSemantic proximity Read ↗

Pleiotropic roles of AEG-1/MTDH/LYRIC in breast cancer.Semantic proximity Read ↗

MiR-128 suppresses metastatic capacity by targeting metadherin in breast cancer cellsSemantic proximity Read ↗

MTDH Promotes Cancer Stem Cell Phenotypes and Correlated with Immune Infiltration in Hepatocellular CarcinomaSemantic proximity Read ↗

The FBXW7 tumor suppressor inhibits breast cancer proliferation and promotes apoptosis by targeting MTDH for degradationSemantic proximity Read ↗

Epigenetic Activation of TWIST1 by MTDH Promotes Cancer Stem–like Cell Traits in Breast CancerSemantic proximity Read ↗

MiR-630 suppresses breast cancer progression by targeting metadherinSemantic proximity Read ↗

LncRNA DDX11-AS1 promotes breast cancer progression via targeting the miR-30c-5p/MTDH axisSemantic proximity Read ↗

MicroRNA-320a inhibits breast cancer metastasis by targeting metadherinSemantic proximity Read ↗

Metadherin promotes stem cell phenotypes and correlated with immune infiltration in hepatocellular carcinoma.Semantic proximity Read ↗

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