Article
Inter-individual differences in HLA expression can impact the CDC crossmatch.
Tissue antigens - 1 Apr 2015
Hönger G, Krähenbühl N, Dimeloe S, Stern M, Schaub S, Hess C
Abstract excerpt
How human leucocyte antigen (HLA) expression levels on human lymphocytes relate to clinically relevant in vitro cytotoxicity testing has not been defined. Here, cross-sectional (n = 14) and longitudinal (n = 6) semi-quantitative assessment of HLA expression on lymphocytes was performed. Complement-dependent cytotoxicity (CDC) and cellular allo-reactivity were assessed vis-à-vis target cells with defined levels of...
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