Magnitude of Off-Target Allo-HLA Reactivity by Third-Party Donor-Derived Virus-Specific T Cells Is Dictated by HLA-Restriction.

doi:10.3389/fimmu.2021.630440

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Article

Magnitude of Off-Target Allo-HLA Reactivity by Third-Party Donor-Derived Virus-Specific T Cells Is Dictated by HLA-Restriction.

Frontiers in immunology - 1 Jan 2021

Huisman Wesley, Leboux Didier A T, van der Maarel Lieve E, Hageman Lois, Amsen Derk, Falkenburg J H Frederik, Jedema Inge

Abstract excerpt

T-cell products derived from third-party donors are clinically applied, but harbor the risk of off-target toxicity via induction of allo-HLA cross-reactivity directed against mismatched alleles. We used third-party donor-derived virus-specific T cells as model to investigate whether virus-specificity, HLA restriction and/or HLA background can predict the risk of allo-HLA cross-reactivity. Virus-specific CD8pos T...

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Topics

Alleles
Cross Reactions
Cytomegalovirus
HLA Antigens
Hematopoietic Stem Cell Transplantation
Herpesvirus 4, Human

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Histocompatibility Testing

Humans

Immunotherapy, Adoptive

K562 Cells

T-Lymphocytes

Tissue Donors

Viruses

Source

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Identifiers

PMID: 33854504
DOI: 10.3389/fimmu.2021.630440
PMCID: PMC8039299

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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