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C3d-binding assay for the detection of complement activating HLA antibodies: A useful tool for allocation to highly sensitised recipients in the post-CDC era?

HLA - 1 Jul 2023

Wong Zo Ee, Downing Jonathan, De Santis Dianne, Halse Megan, Bruce Samuel, Truong Linh, Martinez Patricia, D'Orsogna Lloyd J

Abstract excerpt

The CDC crossmatch test is being phased out in solid organ donor allocation, and standard luminex single antigen bead assays do not differentiate complement activating function of HLA antibodies. The current study investigated the LIFECODES C3d-binding assay to determine if it could accurately predict actual T and B cell CDC results in a cohort of highly sensitised patients. Nineteen serum samples from different...

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Identifiers

PMID: 36851856
DOI: 10.1111/tan.15010

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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