[Mycobacterium tuberculosis mutants with multidrug resistance: history of origin, genetic and molecular mechanisms of resistance, and emerging challenges].

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Article

[Mycobacterium tuberculosis mutants with multidrug resistance: history of origin, genetic and molecular mechanisms of resistance, and emerging challenges].

Genetika - 1 Jan 2012

Prozorov A A, Zaĭchikova M V, Danilenko V N

Abstract excerpt

The review summarizes the data on the Mycobacterium tuberculosis mutations that lead to multidrug resistance (MDR) to various antibiotics. MDR strains arose over the past 30 years as a variety of antituberculosis drugs were introduced in medicine, and they largely discount the results of chemotherapy for tuberculosis. The most dangerous of them are strains with extensive drug resistance (XDR), which are resistant...

Topics

Anti-Bacterial Agents
Antitubercular Agents
Drug Resistance, Multiple, Bacterial
Genome, Bacterial
Humans
Mutation
Mycobacterium tuberculosis
Tuberculosis, Multidrug-Resistant

Source

Open in PubMed

Identifiers

PMID: 22567849

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