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Article

Explant cultures of atopic dermatitis biopsies maintain their epidermal characteristics in vitro.

Cell and tissue research - 1 Sept 2015

van Drongelen Vincent, Danso Mogbekeloluwa O, Out Jacoba J, Mulder Aat, Lavrijsen Adriana P M, Bouwstra Joke A, El Ghalbzouri Abdoelwaheb

Abstract excerpt

Atopic dermatitis (AD) is a common inflammatory skin disorder characterised by various epidermal alterations. Filaggrin (FLG) mutations are a major predisposing factor for AD and much research has been focused on the FLG protein. Human skin equivalents (HSEs) might be useful tools for increasing our understanding of FLG in AD and to provide a tool for the screening of new therapies aimed at FLG replacement. Our...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 25776938
DOI: 10.1007/s00441-015-2162-3

Genes

FLG
KLK5

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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