Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Annexin A2 is SUMOylated on its N-terminal domain: regulation by insulin.

FEBS letters - 13 Apr 2015

Caron Danielle, Boutchueng-Djidjou Martial, Tanguay Robert M, Faure Robert L

Abstract excerpt

Insulin receptor (IR) endocytosis requires a remodelling of the actin cytoskeleton. We show here that ANXA2 is SUMOylated at the K10 located in a non-consensus SUMOylation motif in the N-terminal domain. The Y24F mutation decreased the SUMOylation signal, whereas insulin stimulation increased ANXA2 SUMOylation. A survey of protein SUMOylation in hepatic Golgi/endosome (G/E) fractions after insulin injections...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Annexin A2
Share to Endosomes
Share to Golgi Apparatus

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Hypoglycemic Agents

Share to Protein Interaction Maps

Share to Receptor, Insulin

Share to SUMO-1 Protein

Share to Sumoylation

Source

Identifiers

PMID: 25775977
DOI: 10.1016/j.febslet.2015.03.007

Genes

ANXA2
SUMO1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 10 closest

Annexin A2 is SUMOylated on its N-terminal domain: regulation by insulin.PMID 25775977Read ↗

A type 2 diabetes disease module with a high collective influence for Cdk2 and PTPLAD1 is localized in endosomesSemantic proximity Read ↗

DPP8/9 processing of human AK2 unmasks an IAP binding motifSemantic proximity Read ↗

The ERK5 MAP kinase regulates annexin complexes and membrane dynamics in embryonic stem cellsSemantic proximity Read ↗

SUMOylation of AnxA6 facilitates EGFR-PKCα complex formation to suppress epithelial cancer growth.Semantic proximity Read ↗

Engineering pre-SUMO4 as efficient substrate of SENP2.Semantic proximity Read ↗

Regulation of the Equilibrium between Closed and Open Conformations of Annexin A2 by N-Terminal Phosphorylation and S100A4-Binding.Semantic proximity Read ↗

Structural Basis for Recruitment of the Adaptor Protein APS to the Activated Insulin ReceptorSemantic proximity Read ↗

Coding variants identified in diabetic patients alter PICK1 BAR domain function in insulin granule biogenesisSemantic proximity Read ↗

The IA-2 interactome.Semantic proximity Read ↗

Sumoylation and the oncogenic E17K mutation affect AKT1 subcellular distribution and impact on Nanog-binding dynamics to chromatin in embryonic stem cells.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.