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A type 2 diabetes disease module with a high collective influence for Cdk2 and PTPLAD1 is localized in endosomes

2018-06-07

Abstract excerpt

Despite the identification of many susceptibility genes our knowledge of the underlying mechanisms responsible for complex disease remains limited. Here, we identified a type 2 diabetes disease module in endosomes, and validate it for functional relevance on selected nodes. Using hepatic Golgi/endosomes fractions, we established a proteome of insulin receptor-containing endosomes that allowed the study of physical...

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Literature Corpus work
5fa7a029-0a43-5ca3-9cf6-a72f04f6831c
DOI
10.1101/341693
Open publication

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A type 2 diabetes disease module with a high collective influence for Cdk2 and PTPLAD1 is localized in endosomesDOI 10.1101/341693
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