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Article

Structural organization of a viral IRES depends on the integrity of the GNRA motif

15 Oct 2003

Abstract excerpt

Little is known about the tertiary structure of internal ribosome entry site (IRES) elements. The central domain of foot-and-mouth disease (FMDV) IRES, named 3 or I, contains a conserved GNRA motif, essential for IRES activity. We have combined functional analysis with RNA probing to define its structural organization. We have found that a UNCG motif does not functionally substitute the GNRA motif; moreover,...

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PMID: 14561883
DOI: 10.1261/rna.5950603

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