Susceptibility to tuberculosis is associated with variants in the ASAP1 gene encoding a regulator of dendritic cell migration.

doi:10.1038/ng.3248

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Article

Susceptibility to tuberculosis is associated with variants in the ASAP1 gene encoding a regulator of dendritic cell migration.

Nature genetics - 1 May 2015

Curtis James, Luo Yang, Zenner Helen L, Cuchet-Lourenço Delphine, Wu Changxin, Lo Kitty, Maes Mailis, Alisaac Ali, Stebbings Emma, Liu Jimmy Z, Kopanitsa Liliya, Ignatyeva Olga, Balabanova Yanina, Nikolayevskyy Vladyslav, Baessmann Ingelore, Thye Thorsten, Meyer Christian G, Nürnberg Peter, Horstmann Rolf D, Drobniewski Francis, Plagnol Vincent, Barrett Jeffrey C, Nejentsev Sergey

Abstract excerpt

Human genetic factors predispose to tuberculosis (TB). We studied 7.6 million genetic variants in 5,530 people with pulmonary TB and in 5,607 healthy controls. In the combined analysis of these subjects and the follow-up cohort (15,087 TB patients and controls altogether), we found an association between TB and variants located in introns of the ASAP1 gene on chromosome 8q24 (P = 2.6 × 10(-11) for rs4733781; P =...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 25774636
DOI: 10.1038/ng.3248
PMCID: PMC4414475

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Source receipt: pubmed, retrieved 7 Sept 2026.

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